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The accumulation and misfolding of -syn is due in part to post-translation modification, particularly phosphorylation and nitration that can be exacerbated by oxidative stress (Brembati et al., 2023)

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Strategies to improve bioavailability, half-life in vivo, rapid renal clearance of GH-RH antagonists, and in vivo stability were developed 48,65,69,70,71,72

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