10: Sikiric P, Seiwerth S, Skrtic A, Staresinic M, Strbe S, Vuksic A, Sikiric S, Bekic D, Soldo D, Grizelj B, Novosel L, Beketic Oreskovic L, Oreskovic I, Stupnisek M, Boban Blagaic A, Dobric I
Abstract 2636
Introduction Cardiovascular disease (CVD) is a leading global cause of mortality, primarily driven by atherosclerosis ( Dietary components shape gut microbiome composition and function by providing substrates such as fiber, fat, and protein ( The gut microbiota produces TMA from dietary L-carnitine, choline, phosphatidylcholine, and betaine ( In vitro experiments using colon models have shown that a polyphenol-rich pomegranate extract and the pomegranate polyphenol punicalagin can inhibit microbial TMA production from L-carnitine ( in vivo
Carnitine can support weight loss due to its increased use of fat as an energy source on a low-calorie diet and its improved carbohydrate metabolism
N -Acetylcysteine and methionine replenish glutathione to conjugate the toxic metabolite