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Oxidative stress and GSH deficiency have been linked to abnormalities in nitric oxide metabolism (50)

(11) This has led to the hypothesis that exogenous FOXO protein, such as FOXO4-DRI peptide, may help regulate optimal levels of FOXO proteins, thereby preventing or alleviating the progression of any NDDs associated with this mechanism

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Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have received attention for their effects on brain pathways involved in reward and appetite regulation