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Additionally, high-dose niacin causes significant GI adverse effects (nausea, vomiting, diarrhea, flushing with nausea) and liver stress at prolonged high doses

QTc may be prolonged by this drug, and cardiac monitoring is recommended by electrocardiogram before and with therapy [118]

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Only Resmetirom (a thyroid hormone receptor beta agonist) has FDA approval for this indication although there are several other drugs in the pipeline