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Metformin is widely used because of its low cost, good efficacy and few adverse reactions (Lancet, 1998), but its exact mechanism of action still remains partly unclear

While it shows a reaction between an antioxidant and iodine, it cannot distinguish between glutathione and other antioxidants like Vitamin C

They both significantly influence insulin secretion and plasma glucose excursions after meals or glucose tolerance tests

Since pathomechanisms are not yet fully understood and available treatments are not efficient for all mutation types and tissues, further research is highly needed

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