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4-HNE: 4-hydroxynonenal

Complications worsen the deficiency : Individuals with T2DM who also had microvascular complications (such as damage to small blood vessels in the eyes, kidneys, and nerves) showed even greater reductions in glutathione levels and synthesis rates

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Mitochondria are important sites of ROS generation and fatty acid metabolism and provide specific lipid precursors for ferroptosis to occur in the cell

The gut microbiota harbors a large population of microorganisms in close contact with the intestinal and colonic epithelium