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When treatment intensification is needed beyond metformin, the choice now increasingly favours GLP-1 receptor agonists like Rybelsus for patients who can tolerate the gastrointestinal side effects and afford the higher price

These include pancreatitis (inflammation of the pancreas) and gallbladder disease (including gallstones and cholecystitis), both of which are recognised warnings in the prescribing information for licensed GLP-1 receptor agonists such as semaglutide and tirzepatide

The preclinical mechanistic data from Coskun et al

Learn more: May 2026 (state-dependent rollout): Medicaid access expands through the BALANCE Model

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