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It is an investigational drug that is still under phase 3 clinical trials, in which the researchers are evaluating the safety, dosing, efficacy, and long-term outcome in a larger population

Subsequent research revealed that baicalein decreased erastin-induced ferrous iron levels and erastin-mediated degradation of GPX4, GSH depletion, and lipid peroxidation in the human pancreatic ductal adenocarcinoma cell lines PANC1 and BxPc3 (Xie et al., 2016)

Their effectiveness declines over time and their adverse effects become increasingly more troublesome

This approach mimics how people previously adjusted Saxenda, a daily injection pen that did allow for incremental dose control

They are generally safer than synthetic drugs