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Ertugliflozin Ertugliflozin (Steglatro) is the most recent SGLT-2 inhibitor to come to the market, with approval for use in people with T2D received from the EMA in 2018 and the FDA in 2017

The AACE/ACE, in contrast to the ADA, provides several monotherapy options that are recommended in the following order according to the strength of each recommendation: metformin, GLP-1 receptor agonist, SGLT-2 inhibitor, DPP-4 inhibitor, thiazolidinedione, -glucosidase inhibitor, and an insulin secretagogue (a sulfonylurea or meglitinide)

[1] [2] However, an excessive dose may increase this risk

It is also interesting to me that the use of anticholinergics with GLP-1 agonists doesnt flag as a potential drug even though both can worsen/exacerbate gastroparesis

Rybelsus and weight loss In the same PIONEER 4 study, the researches examined the effect of Rybelsus on weight loss