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Vascular endothelial growth factor (VEGF) is a key mediator of this process, and studies have shown that CSCs often overexpress VEGF, ensuring that the growing tumor receives enough oxygen and nutrients

Additionally, another study demonstrated that the FXR agonist yangonin improved hepatic lipid homeostasis, alleviated cholestasis, and reduced markers of cellular senescence and inflammation in ALD [111]

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doi:10.4291/wjgp.v8.i3.117 Sindhu KN, Sowmyanarayanan TV, Paul A, et al

Metabolism 64:263273 Hadtstein C, Schaefer F (2008) Hypertension in children with chronic kidney disease: pathophysiology and management