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In addition, some researchers have used immunotherapy and synthetic biology to design living bacteria, combining immunotherapy expression with optimized lysis mechanism, so that living bacteria can carry nanobodies back to the core of necrotic tumors, grow to a critical density, and lyse, effectively and continuously releasing therapeutic drugs in the tumor microenvironment

Factors Influencing Dosage Adjustments: Things like other health conditions, how well the body absorbs B12, and any side effects can affect the need for dosage changes

This is called atrophic glossitis