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Current research is predominantly preclinical, with a lack of well-designed human trials to confirm efficacy and safety, and there is insufficient understanding of ACs precise molecular mechanisms and long-term toxicity profiles (Xiao et al

Solvent-carrier risk: Vehicles such as DMSO are potent skin-penetration enhancers with their own irritation and contamination-shuttling risks

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For example, lapatinib induces ferroptosis via iron-dependent ROS generation in the early stages but promotes protective autophagy to facilitate drug resistance in the later stages [157]

Biomarkers of satiation and satiety