Glutathione catalytically detoxifies: hydroperoxides, peroxynitrites, and lipid peroxides.11 Another way glutathione protects cells from oxidants is through recycling of vitamins C and E as shown in Figure 4.10 Another indication of the key roles of glutathione in health is that the accumulation of GSSG due to oxidative stress is directly toxic to cells, inducing apoptosis by activation of the SAPK/MAPK pathway.12 Glutathione depletion triggers apoptosis, although it is unclear whether it is mitochondrial or cytosol pools of GSH that are the determining factor.13 Perhaps the best indicator of the importance of glutathione is that its cellular and mitochondrial levels directly are highly associated with health and longevity
Coffee can be a powerful antioxidant, and there has been a lot of research that has proven its benefits
Age, poor diet, stress, lack of sleep, toxins, and inflammation can all place added demand on the bodys glutathione supply
This page focuses specifically on how undermethylation in autism may affect SAM, creatine production, transsulfuration, glutathione protection and mitochondrial energy
Molecular Cell , 80 (3), 384395
