At high intracellular copper concentration, the carriers are translocated reversibly to the plasma membrane (ATP7A typically to the basolateral, ATP7B to the apical surface) where they efflux excess copper from the cell [206]
Another study published in the Journal of Clinical Endocrinology & Metabolism found that a GLP-1 agonist was effective in reducing body weight and BMI in obese women with PCOS who were also being treated with metformin, a medication commonly used to treat insulin resistance
The highest dose currently being studied in major Phase 3 obesity trials is 12mg once weekly
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Based on experience with the broader GLP-1 receptor agonist class (including semaglutide and tirzepatide), the following additional risks are relevant and should be discussed with a healthcare professional: Acute pancreatitis : Severe, persistent abdominal pain particularly pain radiating to the back may be a sign of pancreatitis and requires urgent medical assessment
