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Am J Physiol Gastrointest Liver Physiol 2002

We estimated that with this sample size, the study would have 80% power to detect an absolute difference in the rate of improvement in ALT of 30 percentage points, with a two-sided type 1 error of 0.05

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Most important, however, are the long-term consequences of thyroid hormone replacement and other therapies on bone health, cardiovascular health, and quality of life that are under-examined in this older population