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The down-regulation of influx transporters of 6-mercaptopurine including SLC28A2 (CNT2), SLC28A3 (CNT3), SLC29A1 (ENT1) and SLC29A2 (ENT2) has been shown to render lymphocyte-derived cell-lines resistant to thiopurines, owing to decreased uptake of thiopurine metabolites into the cells (Peng et al., 2008

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64 The detection of these serum biomarkers, also referred to as DAMPs, may help in the future decision-making of therapeutic designs and transplant evaluations, as well as to identify future potential targets of medical therapy