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However, the combination of GLP-1 receptor agonists with DPP-4 inhibitors have not demonstrated clinically significant additional benefits [116]

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Trophoblasts, in the process of connecting with maternal blood vessels, accelerate villi formation while expanding their surface area, which leads to increased intervillous space perfusion: OS levels are thus increased, triggering the expression of heat shock protein (hsp60 and hsp70), which results in retardation of fetal development and possible pregnancy failure [36]

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