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Hence, in theory, using IL-17 blockers may not be good for those with inflammatory bowel disease

The hypoxic microenvironment of RA joints can cause reactive oxygen species (ROS) accumulation and mitochondrial damage, which not only affect the metabolic processes of immune cells and pathological changes in fibroblastic synovial cells but also upregulate the expression of several inflammatory pathways, ultimately promoting inflammation

There are four PDH kinases (PDK1, PDK2, PDK3, and PDK4) and they are discussed in detail below the Figure

Due to limited data and relatively few clinical trials, many of these interventions need further investigation before they can be considered effective agents for routine clinical use

PubMed 5.Gojkovic S et al