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This process requires specific nutrients, including: Vitamin C : Works synergistically with glutathione and helps to regenerate it

Vitamin A participates in several important homeostatic processes including cell differentiation, antioxidant activity, inflammation, and neuronal plasticity

Additionally, M2-like TAMs upregulate arginase 1 (Arg1), enhancing arginine metabolism and further depleting extracellular arginine, thereby exacerbating immunosuppression (93)

But patients who have tried standard escalation and could not tolerate the side effects often find microdosing lets them stay on treatment long enough to see meaningful outcomes