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2.4.3 Bone turnover markers Fasting blood samples were collected at baseline (n = 20) and at the end of the study (n = 20) via venipuncture, following standard procedures, and the serum was stored until analysis

The JAMA Network Open 2024 trial found that GLP-1 medication combined with exercise produced the greatest weight loss while preserving bone density - while GLP-1 medication alone produced bone loss

They also note that other drugs in the same class as zalfermin, designed slightly differently, may still hold promise and deserve further study

The hygroscopic nature of peptides means absorbed water causes the powder to aggregate

Sales of these GLP-1 treatments drugs that mimic the effects of blood-sugar-regulating hormone GLP-1, a feature originally intended for diabetes care but which also happened to cause weight loss in test subjects have increased by almost 6x since the start of 2018