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The concept of microdosing typically involves starting with doses as low as 0.5 mg to 1.25 mg weekly, which are fractions of the approved 2.5 mg starting dose

Looking ahead for GLP-1s GLP-1s have other potential applications beyond diabetes treatment and weight loss

Also, inhibition of the YAP signal or ferroptosis can significantly rescue POI caused by BNC1 mutation

Slower gastric emptying may reduce rapid post-meal glucose rises for some users

Table 1: Initial use restrictions for Wegovy by commercial plans Source: Clarivate Fingertip Restrictions and payers respective prior authorization documents In addition to a relatively light hand in restricting access, Aetna, Cigna, and Anthem list Wegovy on Tier 2 of their commercial and employer formularies, reflecting widespread coverage for the drug (Fingertip Analytics, accessed February 2024)