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In hemoglobinoathies (mainly SCD and thalassemias, but not limited to), the hemoglobin S and globin dimers are prone to lose heme through the formation of unstable hemichromes [237]

It is the main precursor for the intracellular production of glutathione (GSH)

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Safety and Side Effects: Although glutathione is generally considered safe, its administration via injections raises additional safety concerns