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Two deaths (unrelated to the treatment) were reported in semaglutide group [61]

Any of these warrant staying at the current dose for 2 to 4 additional weeks before attempting the next increase

This phenomenon, called transient worsening, occurs because sudden glucose normalization changes osmotic pressure in the retina, potentially exacerbating microaneurysms or edema already present

The ratio of Dihexa to inulin in the blood was used to correct for any blood contamination in brain regions, while higher ratios in brain regions compared to blood indicated active concentration

A potential contribution of altered cathepsin L expression to the development of dermal fibrosis and vasculopathy in systemic sclerosis