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Therefore, it is imperative to determine whether peripheral ghrelin can activate central targets and the potential mechanisms involved

A medical evaluation helps determine individual risk factors and tolerance

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L-carnitine increases ACE1 and decreases ACE2 in lung and muscle tissue, thereby reducing inflammation by converting angiotensin I to angiotensin II, which plays an anti-inflammatory role [26]

These findings suggest potential neuroprotective benefits of semaglutide, especially regarding cognitive health, and call for further research to validate its use in treating cognitive deficits and substance misuse in patients with T2DM (87)