In temporal lobe epilepsy, levels of astrocytic glutamate transporters in hippocampus are reduced by up to 40%
Improvements in blood sugar levels can be seen within a few weeks, but significant weight loss might take longer, usually around several months
Distinguishing medication-induced anxiety from anxiety triggered by rapid lifestyle change, weight loss expectations, or metabolic stress requires careful tracking and open communication with your care provider
The American Association of Clinical Endocrinology (AACE) 2023 consensus statement on obesity pharmacotherapy recommends dose reduction or titration pause when GI side effects "interfere with daily activities or nutritional intake" 24
The animals were randomly divided into six experimental groups (six rats/group): CTRL group (rats were injected intraperitoneally with saline on day 7 plus Kolliphor EL from day 1- day 10), MTX group (rats were injected MTX intraperitoneally on day 7 plus Kolliphor EL throughout the experiment), NTZ-100 and NTZ-200 groups (rats were injected intraperitoneally with MTX on day 7 plus NTZ (100 and 200 mg/kg, daily) from day 1- day 10 by oral gavage, respectively, plus Kolliphor EL from day 1- day 10) (Elaidy et al., 2018
