MMP 62 is mainly secreted by neutrophils and macrophages, and relies on cofactors such as zinc and calcium to actively degrade the extracellular matrix causing airway destruction and remodeling in COPD patients, 63 and activates the nuclear factor-B signaling pathway, Toll-like receptors and Wnt signaling pathway through a series of reactions, thereby increasing the secretion of MMP and the expression of intercellular adhesion molecules, promoting inflammatory cell aggregation and exacerbating COPD progression
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Dan Henderson, MD, MPH, a primary care physician at Brigham and Womens Hospital and Harvard Medical School whose clinical practice centers on longevity and health span
GLP-1R agonists were initially used to treat T2DM and soon after it was found that these drugs possess many other physiological properties, such as neuroprotection, neurotrophic, and anti-inflammatory effects, which may be useful to slow the progression of AD ( Figure 3 ) ( Figure 3 Anti-inflammatory effects Previous studies have shown that GLP-1R mimics have anti-inflammatory effects in the CNS (139141)
