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Im Gegensatz zu reinen GLP-1-Agonisten wie Semaglutid oder Dualagonisten wie Tirzepatid aktiviert Retatrutid gleichzeitig drei Rezeptoren: den Glucagon-hnlichen Peptid-1-Rezeptor (GLP-1R), den Glukose-abhngigen insulinotropen Polypeptidrezeptor (GIPR) und den Glucagonrezeptor (GCGR)

doi: 10.1172/jci.insight.151544

Although these recent studies appear somewhat conflicting and contentious 28,31,32 , as more studies continue to map out the neuronal gutbrain signaling axis, they could ultimately lead to very precise therapeutics directly targeting specific neural subgroups within vagal afferents to treat specific physiological mechanisms, such as controlling food intake versus intestinal motility