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This means insulin is released only when blood glucose levels are elevated, which reduces the risk of hypoglycaemia compared to some other diabetes treatments (though this risk increases when combined with insulin or sulfonylureas)

There is an increased risk of developing an ulcer or gastrointestinal bleeding when taken with medications like non-steroidal anti-inflammatory drugs or NSAIDs

Gastroenterology (2007) 133:24455

Eight healthy volunteers were given a calorie-restricted diet with either oral MK-677 or a placebo for two 14-day periods