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When clinically appropriate, providers may recommend options such as GLP-1 medications as part of a broader care plan

For instance, research shows MOTS-c drives glucose into the pentose phosphate pathway (for anabolic needs and antioxidant defense) rather than burning it immediately via glycolysis, while simultaneously increasing fatty-acid oxidation by upregulating carnitine shuttle activity in mitochondria

Doctors usually begin with a low dose and slowly increase it over several weeks or months to reduce side effects such as nausea, vomiting, bloating, constipation, reflux, and stomach discomfort

Adequate micronutrient intake, reducing the risk of deficiencies as total food intake drops

However, severe cases involving necrotizing pancreatitis progressing to permanent gastroparesis requiring feeding tubes or surgical intervention could exceed $700,000 to $1 million, particularly when patients can demonstrate complete lifestyle disruption and ongoing medical needs