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See a doctor if you experience: Persistent fatigue Tingling or numbness Memory issues Balance problems Shortness of breath Unexplained weakness Also seek medical advice before taking high-dose B12 long-term, especially if you have existing health conditions
Depression A few observational studies have found higher dietary intakes of vitamin B 12 to be associated with lower risk of developing depression, especially among women
If your dietary sources are insufficient, you may consider supplements, such as pills or injections, depending on the cause of the deficiency
Some protocols recommend taking it on an empty stomach, first thing in the morning, to maximize absorption and align with the natural fasting state when lipolysis is already elevated