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Furthermore, Trigonella foenum-graecum promotes insulin signaling by inducing tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) and phosphoinositide 3-kinase (PI3K), leading to the activation of protein kinase C (PKC) and subsequent translocation of glucose transporter type 4 (GLUT4) to the cell membrane, thereby facilitating glucose uptake [117]

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