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In more serious cases they run the risk of splitting open and causing life-threatening haemorrhages, which in the 1970s was one of the most frequent reasons for emergency surgery

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Tambin se puede utilizar bromoacetato de etilo como materia prima, reducindolo primero con borohidruro de sodio para obtener bromuro de -bromo--hidroxibutirato de etilo, que luego reacciona con trimetilamina para formar una sal de amonio cuaternario, especficamente bromuro de trimetilamonio--hidroxibutirato de etilo