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However, in subsequent investigations in rodent models of depression, (2R,6R)-hydroxynorketamine did not exhibit antidepressant-like effects and increased aggressive behavior (Yang et al., 2019)

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Weekly administration formats demonstrate better adherence than daily regimens

Singly charged ions were discarded, and other ions were selected and subjected to fragmentation at 35% normalized collisional energy for MS2 with a dynamic exclusion of 120 seconds