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Several trials and updated analyses indicate improvements in fasting insulin, HOMA-IR, BMI/waist indices, and lipid parameters, particularly among women with obesity or IR and low baseline 25(OH)D, whereas pooled estimates from other RCTs fail to show consistent effects on fasting glucose or HOMA-IR, likely reflecting underpowered studies and short follow-up (118)

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The lipid-modifying effects should be considered as part of a broader cardiometabolic benefit profile rather than a primary indication for cholesterol management

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