moderate amounts when applied topically can be safe
2023) highlighted the therapeutic potential of three natural compoundshamamelitannin, flavokawain A, and triacetyl resveratrol demonstratingtheir dual anticolon cancer and neuroprotective activities through molecular docking studies, which revealed strong binding affinities to critical targets like BACE1 and CDK8
There is also an increased sensitization of the excitatory neurotransmitter system, such as NMDA glutamate receptors, the reduction in the number of GABA receptors (downregulation), the shift of benzodiazepine receptors to an inverse agonist state, and compensatory changes in other components of the macromolecular GABA/benzodiazepine/chloride ionophore complex (for review see, i.e., [219,220,221,222,223,224,225])
There was no demonstration that I could tell that it was a single pure isolated substance, Mapp said
Some use it for short-term recovery, while others may use it longer for ongoing health benefits