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HCC is the most prevalent form of primary liver cancer and ranks as the second leading cause of cancer-related death globally [48]

HoloTC concentrations followed a similar trend, with the loading dose regimen reaching a median of 300 pmol/L initially, then decreasing to 184 pmol/L at 90 days

G.Di BartolomeoC.et al (2009)

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This approach is an alternative to the traditional strategy of targeting oncogenes and tumor suppressor genes, a strategy that appears complicated because of the high number of genes involved and their ability to drive compensatory pathways 161