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developed a model of Ox-LDL-induced ferroptosis in HUVECs, showing that CTRP13 intervention increased antioxidant enzyme expression, preventing AS and protecting endothelial cells from ferroptosis ( / mice by reducing mitochondrial damage, boosting glutathione and superoxide dismutase levels, and decreasing LPO and MDA levels

Histamine Reactions and Allergic Flares: By neutralizing the reactive oxygen species that act as primary triggers for mast cell degranulation, and by supporting the enzymatic 'brakes' (like SHP-1) on immune cells, NAC can help stabilize hyperactive mast cells

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