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From PDE3B to the regulation of energy homeostasis

Combining weight loss medications like phentermine and Saxenda may compound cardiovascular effects (increased heart rate, blood pressure), gastrointestinal side effects (nausea, vomiting), and central nervous system symptoms (insomnia, anxiety)

Constipation occurs because prolonged colonic transit time increases water absorption from stools, making them harder and more difficult to pass

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The peptide may prove most valuable as an adjunct to post-surgical rehabilitation or for managing small, stable tears conservatively