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Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism

CrossRef Mechanisms of aristolochic acid I Hepatotoxicity: Central role of PDK4-Induced mitochondrial dysfunction and hepatic inflammation Zhaobin Wang, Kunyang Li, Xiaoqi Yi, Yichen Wu, Yang Zhao, Pingping He, Qinghua Zeng, Enxiang Zhang Food and Chemical Toxicology.2025

It is primarily composed of type IV collagen, laminin, fibronectin, nidogen, and basement membrane proteoglycans, forming a dense and intricate meshwork (153)