By integrating microtranscriptomic, Limited Proteolysis-Small Molecule Mapping (LiP-SMap), and small molecule-protein interaction analysis, we find that uridine directly targets poly(rC)-binding protein 1 (PCBP1), thereby suppressing ferroptosis, maintaining mitochondrial function, alleviating oxidative damage, and ultimately improving the quality of aged oocytes
This creates more oxidative byproducts that glutathione helps neutralize
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Glutathione in Patient Care: Key Considerations for Providers Glutathione intersects with multiple physiologic pathways, including inflammation, mitochondrial function, neurotransmission, detoxification, immune balance, and responses to cellular stress
Yu X, Pasternak T, Eiblmeier M, Ditengou F, Kochersperger P, Sun J, Palme K (2013) Plastid-localized glutathione Reductase2-Regulated glutathione Redox Status is essential for Arabidopsis Root apical Meristem maintenance