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In line with this assumption, for all three viruses, we observed a highly significant enrichment of known physical interaction partners of the viral proteome among predicted tier-1 targets compared to tier-2 targets and all other enzymes (Fig

With metabolic disease, autophagy activation can be necessary for fatty acid metabolism during obesity [38], required to reduce cerebral ischemia during DM [39], and necessary to assist with tissue regeneration of muscle [40]