glp-1 and gip Major physiological roles of GIP. Tirzepatide is acting as an GLP-1 vs. GLP-1 + GIP:

Consistent with perturbed glutathione metabolism, CLP mice exhibited significant downregulation of the Nrf2/HO-1 antioxidant axis: reduced Nrf2, a master transcriptional regulator of antioxidant genes, and its target HO-1 were reduced, indicating impaired upstream antioxidant regulation

The multiple linear regression models included covariates such as sex, age, physical activity, alcohol intake, body mass index, estimated glomerular filtration rate, diabetes, hypertension, and dyslipidemia, and included the interaction between the smoking factors and sex

It drives and reflects the aging of every other system

Shishodia G, Toledo RRG, Rong X, Zimmerman E, Xiao AY, Harrison L, et al

(2020) 17:e1003198