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Mechanistically, the use of TMP-195 interferes with the interaction between HDAC9 and STAT1, reduces the deacetylation level of STAT1 in HK-2 cells, and prevents its phosphorylation and reactivation, thereby inhibiting G2/M phase arrest of TECs and alleviating renal tubulointerstitial fibrosis (Zhang et al., 2023c)

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Over the course of two years, Emma saw significant improvements in her insulin sensitivity, lipid profile, and overall metabolic health, reducing her risk of developing related comorbidities