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The same paper also included a nested case-control component of 120,054 patients with T2DM followed for 7.4 years and observed a lower association between dementia and exposure to GLP-1RAs compared with other antidiabetics 39

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2 GLP-1 Lys 26 may form a polar interaction with the receptor, which is presumably enhanced by Arg 20 in exenatide, but creates no steric hindrance

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