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Reintroduce at 2 applications per week, give it 12 weeks, and judge results from photos rather than from how the skin feels day to day

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Our data suggest exendin-P5 may induce a looser coupling between the ligand TMD and G s binding sites, potentially linked to the more short-lived interactions with TMD residues, resulting in higher efficacy due to faster G s conformational transitions associated with nucleotide exchange and faster G s dissociation