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Component scores on a principal component representing variance shared between these five metabolites (ST7) were significantly reduced in residual schizophrenia compared with healthy controls

Pharmacological targeting of CHAC1-mediated processes therefore represents a rational therapeutic strategy, potentially disrupting the cycle of GSH depletion, ER stress amplification and iron-dependent peroxidation that drives neuronal loss

Its large molecular size prevents significant systemic absorption, making it safe for pregnancy use

doi:10.3390/molecules20058742 Lushchak VI

Trimethylaminuria associated with seizures and behavioural disturbance: a case report