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Individualized Treatment : For patients with significant cardiovascular disease or heart failure, the decision to use Ozempic-like drugs must be individualized, weighing the benefits of glycemic control and weight loss against the potential risks, including muscle loss and any unknown cardiovascular effects

It was developed by modifying four amino acids in the native GHRH(1-29) sequence to increase resistance to enzymatic breakdown

In addition, the associations of the GLP-1RA targeted pharmacologic agents with cancer risk should be compared with the use of ILI and metabolic-bariatric surgery for the control of obesity and diabetes

This study was supported by Project of Baima Future Foods Research Institute Undertaken by Best Candidates Selected through Open Competition Mechanism (grant number: JBGS-2021-004), Project of Jiangsu Province older adults health research (grant number: LKM2023050), the Natural Science Foundation of the Higher Education Institutions of Jiangsu (grant no: 24KJB350010), and Youth Science and Technology Project of Suzhou Vocational Health College (szwzy202324)