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Some clinical studies have found elevated lactate levels (395, 396) in ME/CFS patient blood, cerebrospinal fluid, and muscles, suggesting there is reduced oxidative phosphorylation and a switch to anaerobic glycolysis (392, 397399)

All findings referenced are from preclinical research and in vitro studies

1 Introduction At present, depression has become a major mental illness worldwide (1), especially since the COVID-19 pandemic, when the incidence of depression has accelerated by 25% globally (2, 3)

But interesting biology and plausible mechanisms are where drug development begins, not ends

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