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Why GLP1 medications cause diarrhea GLP1 receptor agonists work by slowing gastric emptying and changing how your digestive system processes food

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Multifactorial intervention to reduce cardiorenal disease in type 1 diabetes a prospective, randomised, open, multicenter study the Steno 1 study)

E N D Presentation Transcript INCRETINS Glucagon-like Peptide 1 (GLP-1)and Glucose-Dependent Insulinotrophic Polypeptide (GIP) account for ~90% of the incretin effect In response to equivalent hyperglycemic stimuli, ORAL glucose elicits a greater insulin response than IV glucose Insulin Glucose-Stimulated Secretion of Insulin Glucose GLUT2 Pancreatic Cell SUR Glucose Potassium channel GK K+ Pyruvate GLP-1 ATP + ATP GIP TCA Cycle* AC + Calcium channel cAMP [Ca2+] Amplifying Triggering AC = adenylyl cyclase

[DOI] [PMC free article] [PubMed] [Google Scholar] 41.Tomsi K., Domanjko Petri A., Nemec A., Pirman T., Rezar V., Selikar A., Vovk T., Nemec Svete A