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Doctors may recommend starting at the lower end of the dosing range (e.g., 0.31 mg) or extending the interval between treatments in cases of significant renal impairment

2022 Oct 19;15(10):1283

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Ageing has been associated with various metabolomic profiles including elevated isoleucine, acetylcarnitine, pipecolate, methionine, glutarylcarnitine, 5-hydroxytryptophan, ketoleucine, and hippurate with decreased methylthioadenosine and 3-methyladenine 43 , markers of the carnitine shuttle, sucrose, biopterin, vitamin E metabolism, tryptophan, and tyrosine 44 and elevated cysteine, pantothenic acid, 5-hydroxyindoleacetic acid (5-HIAA), aspartic acid, and glutamate and reduced asparagine and glycerophosphocholine 45